ESPN 53rd Annual Meeting

ESPN 2021


 
Incidence and relapse of idiopathic nephrotic syndrome: meta-analysis
FLOOR VELTKAMP 1 LEONIE RENSMA 1 ANTONIA BOUTS 1

1- AMSTERDAM UNIVERSITY MEDICAL CENTERS, UNIVERSITY OF AMSTERDAM, EMMA CHILDRENS HOSPITAL, DEPARTMENT OF PEDIATRIC NEPHROLOGY, AMSTERDAM, THE NETHERLANDS
 
Introduction:

Idiopathic nephrotic syndrome (INS) in children is, although the most common glomerulopathy in paediatric nephrology, a rare disease in children. Corticosteroids are the cornerstone of the treatment of the first episode, however, relapses occur in the vast majority of children causing considerable morbidity. Differences between ethnicities have been suggested, yet the incidence nor the risk for relapse have been systematically reviewed. Therefore, the objective of this systematic review and meta-analysis was to estimate the overall pooled weighted incidence and risk for relapse of INS in children.

Material and methods:

Using a comprehensive search strategy, MEDLINE and Embase were searched for eligible studies until December 2020. All studies reporting incidence (per 100,000 children/year) and/or risk for relapse (proportion of total of patients who experience at least one relapse) of INS in children (<18 year) were eligible. After quality assessment, the following data were extracted: study (design, localisation, sample size) and patient (age, sex, steroid response, ethnicity) characteristics, incidence, and risk for relapse. The overall pooled weighted estimates were calculated using random-effects meta-analysis, as heterogeneity among studies was expected. In addition, meta-regression was used to test if there was a change over time in incidence and risk for relapse. Sources of heterogeneity were explored by separate subgroup analyses. To test the robustness of the results, subsequent sensitivity analyses were performed. 

Results:

After screening, a total of 73 studies (27 incidence, 54 relapse) were included for analysis. The results will be presented during ESPN 2021.

Conclusions:

 The manuscript was accepted for publication by Pediatrics and its results and conclusions are still under embargo.