ESPN 53rd Annual Meeting

ESPN 2021


 
Epidemiological Trends of Chronic Kidney Disease in Children : A Report from South East of England 2012-2016
JACQUELINE SIT 1 CAROLINE BOOTH 1 NABIL MELHEM 1 MANISH SINHA 1

1- EVELINA LONDON CHILDREN’S HOSPITAL, GUY’S AND ST THOMAS’ NHS FOUNDATION TRUST
 
Introduction:

Chronic kidney disease (CKD) is a devastating illness with profound impact on the child and their families. To our knowledge, there are currently no national registries reporting epidemiology of pre-dialysis or non-dialysis stages of CKD in children. 

 

The objectives of this study were (i) to describe the demographic characteristics of children <16 years with stages 3-5 of CKD in South East of England; (ii) to describe the recent trends in incidence and prevalence; (iii) to describe age, gender and ethnicity-specific incidence; (iv) to compare trends with a previous 5-year period.

Material and methods:

This was a retrospective study of all children <16 years with an estimated glomerular filtration rate of <60ml/min/1.73m2, who were followed up at Evelina London Children’s Hospital between 2012 and 2016. Incidence and prevalence were calculated based on data from the 2011 Census. Results were compared with data from a previous 5-year period (2005-2009). 

 

Results:

There were 292 patients in the study. Renal dysplasia (39.3%) and obstructive uropathy (21.6%) remained the most common causes of CKD. The mean incidence and prevalence of CKD amongst <16 years were 16.7 per million age related population (pmarp) and 110.0pmarp respectively. The incidence of CKD was higher in males (10.5pmarp) compared to females (6.1pmarp). The incidence of CKD was twice as high amongst Asian (24.7pmarp) and Black (21.2pmarp) populations when compared with the White (11.4pmarp) and Mixed (10.0pmarp) populations. The incidence of CKD had remained stable between 13.0pmarp to 20.4pmarp (p=0.62), whilst the prevalence had increased from 105.7pmarp to 118.7pmarp (p=0.04). 

 

Conclusions:

Compared with the previous period 2005-2009, the mean incidence of CKD in the recent 5-year period was similar whilst there was a continued increase in the mean prevalence. This study describes gender, age and ethnicity-specific incidence which have not previously been reported. Understanding the epidemiology of CKD enables appropriate resource allocation and service planning.