ESPN 53rd Annual Meeting

ESPN 2021


 
CARPEDIEM continuous renal replacement therapy for very low birth weight neonates: first experience in Europe
JULIE BERNARDOR 1 GIULIA REGIROLI 2 CAMILLE FAUDEUX 1 BERENGERE FRANCOIS-GARRET 3 SEBASTIEN DAMEZ-FONTAINE 2 SERGIO ELENI DIT TROLLI 3 DANIELE DE LUCA 2

1- DEPARTMENT OF PEDIATRIC NEPHROLOGY, CHU DE NICE, HôPITAL ARCHET, NICE, FRANCE
2- DIVISION OF PAEDIATRICS AND NEONATAL CRITICAL CARE, "A. BéCLèRE" MEDICAL CENTRE, PARIS SACLAY UNIVERSITY HOSPITALS, APHP, PARIS, FRANCE
3- DEPARTMENT OF INTENSIVE CARE AND NEONATAL MEDECINE, CHU DE NICE, HôPITAL ARCHET, NICE, FRANCE
 
Abstract:

 

 

Background: Acute Kidney Injury (AKI) is associated with higher mortality, particularly, in neonates and is a frequent complication (prevalence: 30% of hospitalized patients). Cardio-Renal Pediatric Dialysis Emergency Machine (C.A.R.PE.DI.E.M.) is a new continuous renal replacement therapy (CRRT) equipment dedicated to neonates and small infants weighting 2.0-9.9kg. Methods: We aimed to retrospectively report our experience using CARPEDIEM in very low birth weight and premature neonates treated by continuous venovenous hemofiltration (CVVH). Data are presented as median (25th-75th quartile). Results: Four neonates (median gestational age: 31 (30-34) SA; median birth weight: 1578 (1162-1986) grams) received 145 hours of CVVH during 8 sessions and using 0.15 and 0.25m2 hemofilters. CVVH was conducted using a 4.5 Fr and 6.5 Fr double-lumen central vascular access. The median prescribed Qb was 23 (14-35) mL/min. Circuits were primed with NaCl 0.9%, using heparin anticoagulation (10 to 12UI/kg/h) in all patients. Only two sessions were stopped secondary to a filter clotting. CVVH efficaciously allowed blood purification and fluid balance without hemodynamic instability in all neonates. No survival was reported secondary to basal neonate pathology.  Conclusion: CARPEDIEM is feasible, accurate and safe even in preterm neonates; it has the potential enhance the clinical management of very low birth weight neonates with multisystemic organ dysfunction.