Background: Acute Kidney Injury (AKI) is associated with higher mortality, particularly, in neonates and is a frequent complication (prevalence: 30% of hospitalized patients). Cardio-Renal Pediatric Dialysis Emergency Machine (C.A.R.PE.DI.E.M.) is a new continuous renal replacement therapy (CRRT) equipment dedicated to neonates and small infants weighting 2.0-9.9kg. Methods: We aimed to retrospectively report our experience using CARPEDIEM in very low birth weight and premature neonates treated by continuous venovenous hemofiltration (CVVH). Data are presented as median (25th-75th quartile). Results: Four neonates (median gestational age: 31 (30-34) SA; median birth weight: 1578 (1162-1986) grams) received 145 hours of CVVH during 8 sessions and using 0.15 and 0.25m² hemofilters. CVVH was conducted using a 4.5 Fr and 6.5 Fr double-lumen central vascular access. The median prescribed Qb was 23 (14-35) mL/min. Circuits were primed with NaCl 0.9%, using heparin anticoagulation (10 to 12UI/kg/h) in all patients. Only two sessions were stopped secondary to a filter clotting. CVVH efficaciously allowed blood purification and fluid balance without hemodynamic instability in all neonates. No survival was reported secondary to basal neonate pathology.  Conclusion: CARPEDIEM is feasible, accurate and safe even in preterm neonates; it has the potential enhance the clinical management of very low birth weight neonates with multisystemic organ dysfunction.