ESPN 53rd Annual Meeting

ESPN 2021


 
Aluminum, Lead and Cadmium toxicity and their impact in hematological complications in dialyzed patients
POPA DORIANA MARIA 1 ALDEA CORNEL OLIMPIU 2 ALDEA ANDREEA ALEXANDRA 4 MOLDOVAN MĂRIOARA 3 PRODAN DOINA 3 PERHAIȚĂ IOANA 3 DELEAN DAN 2 BULATĂ BOGDAN 2 BORZAN CRISTINA 1 RĂCHIȘAN ANDREEA LIANA 2

1- DEPARTMENT OF PUBLIC HEALTH, UNIVERSITY OF MEDICINE & PHRAMACY “IULIU HATIEGANU”, 31 AVRAM IANCU STREET, FL 3, 40083, CLUJ-NAPOCA, ROMANIA
2- DEPARTMENT OF NEPHROLOGY- 2ND PEDIATRIC DEPARTMENT, CLUJ-NAPOCA, ROMANIA, 5 CRISAN STREET, 400177, CLUJ-NAPOCA, ROMANIA
3- DEPARTMENT OF POLYMER COMPOSITES, BABES-BOLYAI UNIVERSITY, INSTITUTE OF CHEMISTRY RALUCA RIPAN, 30 FANTANELE STREET, 400294, CLUJ-NAPOCA, ROMANIA
4- NEUROLOGY AND PEDIATRIC NEUROLOGY DEPARTMENT, UNIVERSITY OF MEDICINE & PHRAMACY “IULIU HATIEGANU”, CLUJ NAPOCA, ROMANIA, 46-50, VIILOR STREET, 40066
 
Abstract:

Background: End Stage Renal Disease (ESRD) patients despite receiving adequate extra-renal epuration are developing significant long-term complications.  Abnormalities in the plasmatic heavy metals levels may potentiate the occurrence of these complications. Hence, the present study was undertaken to evaluate the plasmatic trace elements in patients receiving extra-renal epuration. The specific aim of our work was to study the blood levels of aluminium (Al), lead (Pb) and cadmium (Cd) among ESRD patients undergoing haemodialysis (HD) and peritoneal dialysis (PD) and their impact in red blood cells, plasmatic iron and transferrin homeostasis. Materials and methods: It was a longitudinal prospective study done in a tertiary care nephrology center. We enrolled 15 patients (female/male=9/6) with a mean age of 12.80 ±4.51 years old undergoing dialysis (HD and PD) for more than six months. Patients who had history of occupational exposure to heavy metals were excluded from the study. About 5ml of fasting venous blood sample was obtained and analysed for trace elements. To asses the level of trace elements we performed  3 determinations for each patient in predialytic and postdialytic sessions. Results: There was no difference in the mean values for Al, Pb and Cd in pre and post dialytic blood samples. There was a positive correlation for Al and red blood cells (r=0.433, p 0.006); Al and transferrin (r=0.424, p 0.011). A negative correlation was found concerning the Pb and transferrin (r = - 0.402, p 0.03), and Cd and transferrin (r= -0.487, p 0.009). Conclusions: Since high levels of trace elements are potentially harmful, the hypothesis that trace elements level can influence the iron and transferrin status is worthy of investigation.

Keywords: trace elements, chronic kidney disease, dialysis,  hematologic disturbances