ESPN 53rd Annual Meeting

ESPN 2021


 
Renal prognosis in the French cohort (2000-2018) of 46 children with TINU syndrome: we have to be cautious.
CHEVALIER AGNèS 1 CLAVE STEPHANIE 2 BOYER OLIVIA 3 HOGAN JULIEN 4 LAHOCHE ANNIE 5 DECRAMER STéPHANE 6 BROUX FRANCOISE 7 VRILLON ISABELLE 8 ALLAIN-LAUNAY EMMA 9 BACHETTA JUSTINE 10 TANNE CORENTIN 10 ALLARD LISE 11 CLOAREC SYLVIE 12 PIETREMENT CHRISTINE 13 MORIN DENIS 1 FILA MARC 1

1- SERVICE DE NéPHROLOGIE PéDIATRIQUE, CHU MONTPELLIER
2- SERVICE DE PéDIATRIE MULTIDISCIPLINAIRE, CHU MARSEILLE
3- SERVICE DE NéPHROLOGIE PéDIATRIQUE, AP-HP HôPITAL NECKER-ENFANTS MALADES
4- SERVICE DE NéPHROLOGIE - HéMODIALYSE, AP-HP HôPITAL ROBERT-DEBRé
5- SERVICE DE PéDIATRIE - UNITé DE NéPHROLOGIE, CHRU LILLE
6- SERVICE DE PéDIATRIE - NéPHROLOGIE, MéDECINE INTERNE ET HYPERTENSION, CHU TOULOUSE
7- DéPARTEMENT DE PéDIATRIE MéDICALE, CHU ROUEN
8- SERVICE DE PéDIATRIE, CHU NANCY
9- SERVICE DE NéPHROLOGIE ET IMMUNOLOGIE CLINIQUE, CHU NANTES
10- SERVICE DE NéPHROLOGIE-RHUMATOLOGIE-DERMATOLOGIE PéDIATRIQUES, CHU LYON
11- SERVICE DE PéDIATRIE MéDICALE, CHU BORDEAUX
12- SERVICE DE NéPHROLOGIE – HéMODIALYSE PéDIATRIQUE, CHRU TOURS
13- SERVICE DE PéDIATRIE GéNéRALE ET SPéCIALISéE, CHU REIMS
 
Introduction:

TINU syndrome is a rare disease, defined by the association of acute tubulointerstitial nephritis and uveitis. The renal prognosis in children with this disease is usually known to be good and better than in the adulthood. Owing the small number of data available in this field, we sought to precise the long term renal prognosis in a French cohort of children with tubulointerstitial nephritis and uveitis syndrome.

Material and methods:

We performed a national retrospective study including 23 french pediatric nephrology units, collecting patients with tubulointerstitial nephritis and uveitis syndrome diagnosed between January 2000 and December 2018.

Results:

46 patients were included (52% females, median age 13.8 years). At tubulointerstitial nephritis diagnostic, the median estimated glomerular filtration rate was 30,6 mL/min/1.73m² (4,9 - 62,8). The median time between the diagnosis of uveitis and tubulointerstitial nephritis was 0.4 months (-4.1 to +17.1m). All patients had anterior uveitis but among them 12 (28.6%) had no ophthalmologic symptoms. At last follow-up (median 2.8 years), the median estimated glomerular filtration rate was 87.5 mL/min/1.73m² (60,3 – 152,7) with 20 less than 90 mL/min/1.73m².

Conclusions:

 In our study, more than half of the patients had a poor renal outcome at last follow-up. Given the possible progression to chronic renal disease, long-term monitoring of patients with tubulointerstitial nephritis and uveitis syndrome is mandatory. Worthy of note, 25% of patients had asymptomatic uveitis so an ophtalmological exam in patients with tubulointerstitial nephritis is necessary even in the absence of ocular signs.