ESPN 53rd Annual Meeting

ESPN 2021

the survey of association between peritoneal dialysis fluid CA125 and peritoneum function in PET test in peritoneal dialysis patients


Over time, changes in the peritoneal membrane lead to changes in soluble material transfer and reduced ultrafiltration. Finding a measurable biomarker in peritoneal effluent with the ability to predict the progression of membrane damage or failure is of interest. One of these markers is CA125 antigen, which is considered as a measure of the health and mass of peritoneal lining mesothelial cells. So far, few studies have examined this issue in the age group of children. The aim of this study was to evaluate the relationship between dialysate CA125 concentration and peritoneal function in PET and its changes over time.

This is a cross-sectional study conducted in patients under 18 years of age with peritoneal dialysis during the years 2014-march 2019. After selection of patients according to inclusion and exclusion criteria, demographic information, PET test result, serum concentration and dialysis CA125 were collected according to the prepared checklist. To investigate the relationship between dialysis duration and dialysate CA125, patients were divided into two time groups (12 and >12 months). Patients undergoing more than two PET tests were examined for longitudinal changes in dialysis concentration of CA125 over time.

75 PET tests were performed during this period. 46 males (62.2%) and 29 females (38.7%) were studied. The mean and standard deviation of age was 7.81±4.12 years. Peritoneal dialysis duration in patients was 3-91 months with mean and standard deviation 27.61±19.89 months. None of the patients had peritonitis at the test time and 2 months prior. The dialysis concentration of CA125 protein was 0.6-40.50 U/ml. CA125-AR was significantly higher in patients in the short-term group (19.29±16.02 compared to 11.09±10.79, P = 0.034) but with time there was no significant change in the peritoneal transfer parameters. There was no association between CA125-AR and the occurrence of peritonitis and EPS, although it was lower in the group with a history of peritonitis or EPS (P <0.05). There was no significant relationship between CA125-AR and PET test for creatinine and glucose (P >0.05). There was no significant correlation between dialysate CA125 and CA125-AR in ultrafiltration failure group campare to normal group. In the longitudinal study of patients, the trend of decrease in CA125 and CA125-AR from test 1 to 3 was significant (P=0.04 and P=0.013, respectively).

Conclusion: It can be assumed that in the first few years of peritoneal dialysis, the duration of dialysis has no effect on the level of dialysis CA125. In addition, age, sex, and peritoneal transport characteristics do not appear to affect the level of CA125 dialysis. Changes in peritoneal lining mesothelial cell mass cannot be assessed by cross-sectional determination of CA125. Longitudinal evaluations may be more valuable in the follow-up of patients.