ESPN 53rd Annual Meeting

ESPN 2021


 
RELATIONSHIP BETWEEN THE ESTIMATED GLOMERULAR FILTRATION RATE AT ONE MONTH AFTER TRANSPLANTATION AND THE CHANGE OF GRAFT FUNCTION IN PAEDIATRIC LIVING RENAL TRANSPLANT RECIPIENTS
Junya Hashimoto 1 Yuko Hamasaki 1 Mai Kubota 1 Yujiro Aoki 1 Masaki Muramatsu 1 Takeshi Kawamura 1 Seiichiro Shishido 2 Ken Sakai 1

1- Department of Nephrology, Toho University Faculty of Medicine
2- Department of Pediatric Nephrology, Toho University Faculty of Medicine
 
Introduction:

This study was performed to evaluate the usefulness of the estimated glomerular filtration rate at one month after transplantation (eGFR-1M) in predicting the change of graft function in paediatric living renal transplant recipients.

Material and methods:

The 43 paediatric recipients were classified as those with eGFR-1M ≥ 90 ml/min/m2 (n = 19; Group A) and those with eGFR-1M < 90 (n = 24; Group B). In Group A and B, changes in eGFR were evaluated for five years after renal transplantation retrospectively.

Results:

The mean recipient age at transplantation in Group A / B was 6.1±3.4 / 7.8±4.0 years (P=0.14). In both groups, more than 50% of the recipients had congenital anomalies of the kidney and urinary tract (CAKUT) as their primary diseases. The mean eGFR-1, 12 and, 60 M (ml/min/1.73m2) in Group A / B were 106.8±2.99 / 78.5±1.52 (P<0.0001), 79.3±3.22 / 62.7±2.38 (P=0.0001), and 73.1±4.16 / 59.2±2.79 (P=0.006), respectively. During the observation period, the mean eGFR of Group A was always higher than Group B. Compared with Group A, the odds ratio for Group B to have an eGFR-60M <60 ml/min/1.73 m2 was 4.5 (CI, 1.04-19.7; P = 0.04). The mean recipient body weight and body surface area ratio for recipient to donor at transplantation in Group A / B were 15.0±5.2 / 21.4±13.1 (P=0.04) and 0.38±0.08 / 0.49±0.19 (P=0.046), respectively. There were no significant differences in donor age, the number of recipients with CAKUT as primary disease, acute rejection and BK nephropathy between both groups.

Conclusions:

The eGFR-1M could be useful in predicting the change of graft function in paediatric living renal transplant recipients. Our study also suggested an interesting finding that body size mismatch between donor and recipient could affect graft function up to five years after transplantation.